Offering luggage storage, Serafino B&B Palermo lies in La Kalsa, which is a great choice for travellers interested in architecture, history and monuments, a mere 650 metres from Regional Archeological Museum Antonio Salinas and approximately 10 minutes' walk from Piazza Marina. This Palermo hotel features Wi-Fi, provided in the rooms.

The monumental Fontana Pretoria Fountain is merely 0.6 km away, while Palermo Central train station is in proximity to the bed & breakfast. The Serafino B&B Palermo provides history lovers with proximity to the 12th-century palace "Castello della Zisa" (2.5 km) and the grand 9th century Norman Palace (1.5 km). Guests will also appreciate the vicinity to Villa Giulia, located around 5 minutes away by car. There is Cuba Palace 2.1 km away, and Via Paolo Balsamo bus station is only 0.8 km from the property.

The 10 rooms at Serafino B&B comprise a mini-kitchen. There is also a private bathroom.

The daily dining options include an Italian breakfast. You can enjoy Sicilian cuisine in Antica Focacceria San Francesco, situated close at hand, about a 5-minute walk away.