Situated approximately a 5-minute walk from Oreto River, the 4-star San Paolo Palace Hotel Palermo includes 280 rooms. This Palermo hotel lies in proximity to Orto Botanico, and offers an à la carte restaurant and an outdoor swimming pool onsite.

The regional contemporary art Museum Palazzo Riso is about 2 km from the hotel, while Food Market is 2.1 km away. History lovers will enjoy visiting the grand 9th century Norman Palace (2.5 km) and the 12th-century palace "Il Castello della Zisa" (3.3 km). Hills are next to the San Paolo Palace Palermo. The nearby cultural attractions include Museum of tiles Stanze al Genio, which is within 25 minutes' walk of the accommodation. This smoke-free hotel is 300 metres from Messina Marine - Cappello bus stop and within a few blocks of Palermo Central train station in Palermo.

San Paolo Palace Hotel welcomes guests to the air-conditioned rooms with comforts such as a flat-screen TV with satellite channels and pay-per-view channels, along with a mini-bar. Providing a bidet and a separate toilet, the bathrooms also have hair dryers and towels. The rooms overlook the sea.

There is a free buffet breakfast served at this accommodation. The hotel offers a lounge bar and a restaurant serving Italian cuisine. Guests may find the seafood restaurant Agrodolce in the immediate vicinity of the San Paolo Palace.