Dating back to the 14th century, the unique 5-star San Domenico Palace, Taormina, A Four Seasons Hotel features Wi-Fi, a private parking lot, and limousines for rent. The historical hotel offers a banquet hall and a ballroom and sits only 1.9 km from the Castle of Castelmola.

The grand hotel is located in the very heart of Taormina about 5 minutes on foot from the Corso Umberto and a few moments from the historic medieval Catholic church "Basilica of St. Nicholas of Bari". The San Domenico Palace, Taormina, A Four Seasons is also 2.8 km from the Spisone Beach and km from Isola Bella bay. Guests might as well enjoy proximity to Lady Florence Trevelyan Park, situated merely 550 metres away. The accommodation is a stone's throw from the arched Porta di Catania Gateway. San Domenico Palace, Taormina, A Four Seasons Hotel is near a boat dock and Rocca bus stop is just 0.6 km away.

Overlooking the sea, some rooms at this Taormina hotel feature soundproof windows furnished with a writing desk. Guests can make use of a mini-fridge-bar, tea and coffee making equipment, and relax with a flat-screen TV with satellite channels. For more comfort, dressing gowns and shower caps, along with a bidet, are provided.

A buffet breakfast is served each morning at the San Domenico Palace, Taormina, A Four Seasons. The à la carte Anciovi restaurant in the property offers dishes for dinner. The restaurant at the hotel has Italian menu. Drinks are available at the lounge bar. There is a restaurant serving Sicilian food nearly a 5-minute walk away.