Nestled in Ortigia, which is the historical centre of Siracusa, Samuel Room Syracuse hotel is approximately a 15-minute walk from the ancient Greek Temple of Apollo.

The 17th-century Basilica Santa Lucia al Sepolcro is merely 550 metres away, while Siracusa train station is within a few blocks of the guest house. It is within 25 minutes' walk of the art museum "Bellomo Palace Regional Gallery". Only 1.6 km from the Samuel Room, guests will also find the Piazza del Duomo. Piave 1 bus stop is at a distance of a short way from the hotel.

This accommodation offers rooms with a balcony complete with climate control. Bathrooms have a separate toilet and a shower, along with hair dryers and towels.

Caseificio Borderi is located next to Samuel Room hotel and serves healthy dishes, 16 minutes' walk away.