Situated about 15 minutes' walk from the food markets of Palermo, the 4-star Reginella B&B Palermo is adorned with tiled floors, offering essentials such as Wi-Fi and parking. The bed & breakfast lies in the Monte di Pieta district of Palermo, within reach of such cultural sights as the Diocesan Museum of Palermo.

The animal park "Parco D'orleans" is merely 1.2 km away, and the catholic Church of San Cataldo is a mere 1.3 km from this Palermo hotel. Teatro Massimo is also only 7 minutes' walk away. Guests might as well visit Bastione Guccia, which is 450 metres away. Located approximately 5 minutes' drive from the Reginella B&B Palermo, the burial Capuchin Catacombs is open for visiting by worshippers and tourists. The nearest bus stop is Papireto - Piazza del Noviziato 300 metres away.

The soundproof rooms comprise a balcony, and offer a flat-screen TV with satellite channels along with a mini fridge bar, tea and coffee making equipment. The rooms also have tile flooring. Bathrooms are fitted with a bidet, a separate toilet, and a shower as well as hairdryers and bath sheets.

An Italian breakfast is available daily at the Reginella B&B. The property invites guests to have a drink at a lounge bar. Serving a wide assortment of dishes, L'Acerba Osteria Dinamica is in the immediate vicinity of the hotel.