Offering a hot tub and a sauna, Regina Suite Palermo hotel is nestled merely 5 minutes' walk from the Monument to Giuseppe Garibaldi and 3.4 km from the 1500s Catalan Gothic–style palace "Palazzo Abatellis". This 4-star guest house features cars for rent, as well as Wi-Fi throughout the property.

Situated within 3 km of the Baroque Quattro Canti Square, the hotel also gives access to such sports venues as Stadio Renzo Barbera Football Stadium, which is 1.7 km away. The grand 9th century Norman Palace is only a few steps from the Regina Suite, while Villabianca - Autonomia Siciliana bus stop is approximately 5 minutes' walk away. Guests can visit historical sights, including the 12th-century palace "Castello della Zisa", located 2.7 km from this accommodation, and learn more about Palermo. For those travelling from afar, Falcone-Borsellino airport is 25 minutes' drive away.

Regina Suite hotel offers rooms with a seating area and a dining area featuring an iron and an air conditioner, along with a personal computer and a flat-screen TV with satellite channels. They are appointed with a writing desk, and also feature a minibar fridge, tea and coffee-making facilities. Bathroom comforts include a hairdryer and towels, and such essentials as a bidet, a separate toilet, and a shower. Guests can enjoy views of the garden from the Regina Suite Palermo.

This hotel offers a daily Italian breakfast. There is a seafood restaurant serving Sicilian food around 300 metres away.