Hotel Regina Palermo has 14 rooms and is located 2.3 km from the 12th-century palace "Castello della Zisa". Guests can take advantage of a private parking lot for EUR 15 per day nearby.

The hotel is centrally situated nearly a 25-minute walk from Giardino Inglese Garden. The medieval Church of San Giovanni degli Eremiti also lies within reach of this Palermo hotel. The Regina Palermo is an ideal starting point for visiting Massimo Theater, located just 650 metres away. The nearest bus stop is Piazza Pretoria, approximately 10 minutes' walk away.

Guestrooms offer a balcony, along with a writing table for guests' comfort. Bathrooms, equipped with a separate toilet and a shower, also feature shower caps and bath sheets.

Pizzeria Frida serves a good range of Sicilian food and lies 350 metres from Hotel Regina.