The elegant Palazzo Santamarina Luxury Suite & Spa Palermo hotel, located in the Monte di Pieta district, about a 5-minute walk from the regional contemporary art Museum Palazzo Riso, offers bicycles and rental for rent. Overlooking the city, this 4-star guest house lies just near the Baroque Quattro Canti Square and includes a Turkish steam bath, a treatment room, and a hot tub.

The hotel has a prime setting just 1 km from the grand 9th century Norman Palace, while natural sights like Foro Italico Lawn are a mere 1.6 km away. The property is within 10 minutes' walk of the monumental Fontana Pretoria Fountain and in proximity to Massimo Theater. Shopping enthusiasts will enjoy being 350 metres from the grand square "Piazza Pretoria". The Palazzo is directly connected with Palermo Central train station, which is around 15 minutes' walk away.

The air-conditioned rooms are fitted with air conditioning and soundproof walls; such modern facilities as a flat-screen TV with satellite channels, and include private bathrooms with a walk-in shower, a separate toilet, and a hot tub. Also, there is an individual safe, a mini-bar, tea and coffee making facilities provided.

This Palermo hotel offers a daily continental breakfast. Pizzeria Frida offers a selection of Southern-Italian delicacies and lies right around the corner from the Palazzo Palermo.