Located only 1.7 km from the food markets of Palermo, One Hotel Palermo is only a 5-minute walk from the regional contemporary art Museum Palazzo Riso. There is private parking nearby and Wi-Fi throughout the property.

The guest house is about 35 km from Falcone-Borsellino airport and in proximity to such cultural venues as the monumental Porta Felice City Gate. Chiesa di San Domenico Baroque Church is 400 metres from the One Palermo, and the Antonio Salinas Regional Archeological Museum is approximately 450 metres away. This 4-star hotel is located 20 minutes on foot from the 17th-century Church of the Gesu. Roma - Poste bus stop is at a distance of steps away from the property.

The rooms at One Hotel provide guests with a flat-screen TV with satellite channels, as well as comforts such as an iron with ironing board and air conditioning. The bathrooms come with a bidet and a separate toilet, along with a hair dryer and complimentary toiletries.

This hotel offers a continental breakfast which includes fresh pastries and fresh fruits. Offering Mediterranean dishes, Ristorante Palazzo Branciforte lies 50 metres away.