Offering a private beach area and a restaurant, the comfortable 4-star Mille E Una Notte House Syracuse hotel lies in Pearl District with converted industrial buildings brimming with independent boutiques, brewpubs, global restaurants, and art galleries, 2.2 km from the Paolo Orsi Regional Archaeological Museum and merely 11 minutes on foot from such cultural places of interest as the Sicilian art museum "Bellomo Palace Regional Gallery". This Syracuse bed & breakfast also entices guests with shuttle service.

The hotel has a central setting 2.1 km from the Neapolis Archaeological Park, while natural sights like the sinuous ancient Ear of Dionysius Cave are 2.5 km away. The Mille E Una Notte House Syracuse is only a 5-minute stroll from Archimede bus stop and right around the corner from the ancient Greek Temple of Apollo. The nearby entertainment attractions of Syracuse include Teatro dei Pupi, which is 750 metres away. Siracusa station is about 15 minutes on foot from the accommodation.

Climate control as well as a kitchen are featured in the rooms for guests' convenience.

Offering European meals, Room Cucina is situated only a few steps from Mille E Una Notte House hotel.