Located 400 m from Teatro dei Pupi, Matteotti 21 Rooms Syracuse hotel is approximately a 5-minute walk from the Piazza del Duomo.

The guest house is a stone's throw from the baroque palace "Palazzo Beneventano Del Bosco" in Ortigia, which is the historical centre of Siracusa. Attractions 450 metres from this Syracuse hotel include the Church of St. Philip the Apostle. The Neapolis Archaeological Park is around 2 km from the Matteotti 21 Rooms Syracuse. The accommodation is located in close proximity to Siracusa train station, while Archimede bus stop is just 5 minutes' walk away.

The rooms comprise a balcony complete with air conditioning, as well as a multi-channel television. Appointed with soundproof windows, the rooms also come with coffee and tea making equipment. For more comfort, hair dryers and dressing gowns, along with a bidet, a walk-in shower, and a separate toilet are provided.

The seafood restaurant Sicilia in Tavola is located just a few steps from Matteotti 21 Rooms hotel.