The 3-star smoke-free La Serenissima Hotel Palermo is situated in a busy area of Palermo, 2.4 km from the burial Capuchin Catacombs and approximately 25 minutes' walk from the Cuba Palace. Located in proximity to Teatro Massimo, this Palermo hotel overlooks the city and invites guests to have a drink at a lounge bar.

The hotel is about 35 km from Falcone-Borsellino airport and 500 m from such cultural venues as Modern Art Regional Gallery Sant'Anna. The La Serenissima Palermo offers proximity to natural sights like the Orto Botanico (1.1 km) and Giardino Inglese Garden (2 km). Also, Giardino Garibaldi is situated nearly a 5-minute walk away. There is the medieval Church of San Giovanni degli Eremiti merely 1.8 km from the property. La Serenissima Hotel is located only a few steps from Palermo Central train station, while Cala - Mercato Ittico bus stop is just a 5-minute stroll away.

The rooms comprise a balcony complete with an air conditioner, as well as a flat-screen TV with satellite channels. Furnished with a wardrobe and a writing table, they also have sound-proof windows. The bathroom features a lowered sink, a raised toilet, and a shower, along with a hairdryer and toiletries.

The La Serenissima offers a buffet breakfast made fresh daily. Situated about 300 metres from the hotel, the restaurant Antica Focacceria San Francesco offers a Mediterranean menu.