The comfortable La Serenissima Hotel Palermo enjoys a prime location only 6 minutes' walk from the Church of San Francesco of Assisi and offers 12 rooms with views of the city. The 3-star smoke-free hotel is located in a busy area, in proximity to the Baroque Quattro Canti Square.

Nestled approximately 500 metres from Modern Art Regional Gallery Sant'Anna, this Palermo hotel is approximately 550 metres from the Oratory of Saint Lawrence. The La Serenissima Palermo offers proximity to natural sights like the Orto Botanico (1.1 km) and the Foro Italico (1.2 km). Guests might as well visit Giardino Garibaldi, which is nearly a 5-minute walk away. Also, the property is within reach of the Museum of Tiles Stanze al Genio, and Palermo Central train station is located merely 1.1 km away. La Serenissima Hotel is around a 5-minute drive from Cala - Mercato Ittico bus station.

The air-conditioned rooms offer free Wi-Fi and a flat-screen TV with satellite channels along with air conditioning and soundproof walls. There are separate bedrooms and private bathrooms with a bidet, a separate toilet, and a rainfall showerhead provided. Featuring a bidet, a separate toilet, and a shower, the bathrooms also come with a hairdryer and bath sheets.

The La Serenissima offers a buffet breakfast made fresh daily. Guests can enjoy the lounge bar on premises. The bar area includes a terrace and a lounge. Antica Focacceria San Francesco has its own variety of Mediterranean meals and is 300 metres away.