The 3-star Kairoli Square Hotel Messina provides proximity to the Basilica of Saint Anthony of Padua, which is located only 1.2 km away.

The centre of Messina can be reached in 10 minutes' walk of the guest house, and such cultural venues as the Statue of John of Austria are merely a 7-minute stroll away. Standing just 600 metres from the Messina Cathedral, the hotel is just 1.4 km from the Palace of Culture of Messina. The Kairoli Square Messina is situated steps away from the bastioned Forte Gonzaga, and Cavallotti bus station lies a mere 5 minutes' walk away. The accommodation in Messina is 30 km from Reggio di Calabria Tito Minniti airport.

The rooms overlook the city and feature a flat-screen TV with satellite channels along with tea and coffee-making facilities. Climate control are featured for guests' comfort. Featuring amenities such as a hairdryer and towels, the private bathrooms come with a bidet, a separate toilet, and a shower.

Situated a few steps from Kairoli Square Hotel, the cafeteria Bar Astoria piazza Cairoli offers an Italian menu.