The 4-star D'Ossuna66 Suite & Spa Palermo hotel is located nearly 25 minutes' walk from Ustica Island and features a Jacuzzi and a sauna. The guest house is a good starting point for exploring Palermo, including Teatro Massimo, which is merely 0.7 km away.

This Palermo hotel is about 35 km from Falcone-Borsellino airport and in proximity to such cultural venues as the Gemmellaro Geological Museum. The 12th-century Church of San Cataldo is 19 minutes' walk away, while the Paleo-Christian Catacombs of Porta d'Ossuna is a mere 500 metres from the D'Ossuna66 Suite & Spa Palermo. The 17th-century Oratory of the Rosary of St. Cita Chapel is not far from the accommodation. Alberto Amedeo - Tribunale bus stop is just a 5-minute stroll from the hotel.

The rooms at D'Ossuna66 Suite & Spa hotel have a flat-screen TV with satellite channels, along with a mini-fridge-bar and coffee/tea making facilities for your convenience. Furnished with a writing table, they also have sound-proofed windows. Guests have access to a bidet, a walk-in shower, and a separate toilet, as well as bathroom comforts such as hair dryers and a shower cap.

The seafood restaurant Trattoria Mamma Ciccina is located just a few steps from the D'Ossuna66 Suite & Spa.