Located just 1.4 km from the Baroque Quattro Canti Square, D'Ossuna66 Aquarium Palermo hotel is 6 minutes' walk from the Paleo-Christian Catacombs of Porta d'Ossuna. This guest house also provides guests with a safe deposit box and 24-hour security.

The 3-star hotel is about 35 km from Palermo International airport and 25 minutes' stroll from such cultural venues as the Antonio Pasqualino International Puppet Museum. Teatro Massimo is within reach of the D'Ossuna66 Aquarium, and the medieval Church of San Giovanni degli Eremiti is 1.5 km away. There is the art museum "Palazzo Abatellis" 10 minutes away by car, while Piazza Don Sturzo bus station is within 15 minutes' walk of this property.

The hotel offers rooms with a balcony and a dining area featuring an air conditioner, along with a flat-screen TV with satellite channels. Other comforts include coffee and tea making equipment, and a fridge for self-catering. They feature bathrooms with a bidet, a separate toilet, and a shower as well as hairdryers and bath sheets.

Kistema offers Italian dishes and lies just around the corner from D'Ossuna66 Aquarium hotel.