Located in the shopping Ruggero Settimo district, Donna Isa B&B Palermo is only 8 minutes on foot from such culture-oriented attractions as Massimo Theater. This smoke-free bed & breakfast features Wi-Fi throughout the property and 6 rooms that offer views of the city.

Nestled just 1.9 km from Food Market, the property is within a 5-minute drive of the burial Capuchin Catacombs. The hotel provides history lovers with proximity to Norman Palace (1.9 km) and Zisa Castle (1.6 km). The accommodation is situated just a short drive from Foro Italico Park, and Piazza Don Sturzo bus station lies approximately 10 minutes' walk away. For those travelling from afar, Falcone-Borsellino airport is 29 minutes' drive away.

All allergy-friendly rooms at the Donna Isa B&B Palermo are equipped with a flat-screen TV with satellite channels along with coffee and tea making facilities for self-catering. Furnished with a writing desk, they also have sound-proofed windows. Offering amenities such as complimentary toiletries and dressing gowns, the private bathrooms have a bidet and a rainfall shower.

The Donna Isa B&B provides a free breakfast every morning. Il Culinario serves Southern-Italian dishes and lies just 5 minutes' walk from the property.