Located merely 1.2 km from the Paolo Orsi Regional Archaeological Museum, Casamia Hotel Syracuse is about 5 minutes' walk from the Monument to Syracuse Fallen in Africa. Guests who stay at the guest house can park their car on site.

The Rossana Maiorca Bike Trail is a mere 10 minutes' walk away, while Siracusa train station is around 25 minutes on foot from this Syracuse hotel. Also, there is the Church of Santa Maria dei Pericoli just a few steps from the Casamia Syracuse. The ancient Greek Temple of Apollo is situated within a 3-km distance of the accommodation. The hotel is in the immediate vicinity of Puglia bus stop.

The rooms comprise a balcony complete with air conditioning, as well as high-speed internet and a multi-channel television. Appointed with sound-proofed windows, the rooms also come with tea and coffee-making facilities. Guests can take advantage of a bidet, a walk-in shower, and a separate toilet, along with hairdryers and shower caps supplied in the bathrooms.

Serving Italian meals, Bar Bonta E Tradizioni lies 600 metres from Casamia Hotel.