Located merely 1.9 km from the royal Palatine Chapel, Calisa Hotel Palermo is a mere 6 minutes' walk from the unfinished Santa Maria dello Spasimo Catholic Church. Private car parking is available nearby.

The guest house is right near Orto Botanico in La Kalsa, which is a great choice for travellers interested in architecture, history and monuments. Modern Art Regional Gallery Sant'Anna is 950 metres from the Calisa Palermo, while Roma FS bus stop is about a 5-minute walk away. The hotel also takes you to Church of Saint Catherine of Alexandria, which is just 1.1 km away. Palermo Central train station can be found in close proximity to the property.

This Palermo hotel offers rooms with a balcony and a seating area featuring ironing equipment, along with a multi-channel TV. Self-catering facilities include a refrigerator, an oven, and kitchenware. They feature bathrooms with a bidet, a separate toilet, and a shower as well as hairdryers and bath sheets.

The restaurant Antica Focacceria San Francesco is within 5 minutes' walk of Calisa Hotel.