Palazzo Napolitano Bed & Breakfast Palermo lies nearly a 15-minute walk from Chiesa di San Domenico Baroque Church, and features baggage storage. Street parking is available nearby.

The bed & breakfast is located in La Kalsa, which is a great choice for travellers interested in architecture, history and monuments and offers to visit Martorana Church, which is merely 600 metres away. Within a few blocks of the Palazzo Napolitano Bed & Breakfast you will reach the Antonio Pasqualino International Puppet Museum. Guests might as well enjoy proximity to Giardino dei Giusti, situated a mere 6 minutes' walk away. The hotel is also 2.1 km from the Cuba Palace and Via Paolo Balsamo bus station is 300 metres away. This accommodation provides a place to stay just steps from the Palermo Central train station.

Palazzo Napolitano Bed & Breakfast offers rooms with a balcony featuring an air conditioner, along with a multi-channel television. They are appointed with a writing desk, and also feature a mini fridge bar. Bathroom amenities include a bidet, a roll-in shower, and a separate toilet, as well as comforts such as hairdryers and towels. Guests can enjoy views of the city from this Palermo hotel.

Located 8 minutes on foot from the Palazzo Napolitano Bed & Breakfast Palermo, the restaurant Antica Focacceria San Francesco offers a Sicilian menu.