Overlooking the city, Palazzo Napolitano Bed & Breakfast Palermo is nearly a 15-minute walk from the Piazza Marina. Featuring luggage storage, this bed & breakfast is located within a few blocks of the cathedral church "Cattedrale di Palermo".

The hotel is about 35 km from Falcone-Borsellino airport and only 600 m from such cultural venues as the Gemmellaro Geological Museum. Teatro Massimo is within reach of the Palazzo Napolitano Bed & Breakfast in Palermo. Guests might as well enjoy proximity to Giardino dei Giusti, situated a mere 6 minutes' walk away. There is the 1500s Catalan Gothic–style palace "Palazzo Abatellis" merely 1.2 km away, and Via Paolo Balsamo bus station is 300 metres from this accommodation.

Palazzo Napolitano Bed & Breakfast offers rooms with a balcony featuring air conditioning, along with a multi-channel television. They are appointed with a writing table, and also feature a mini fridge bar. Bathroom essentials include a bidet, a roll-in shower, and a separate toilet, and such comforts as hairdryers and towels.

Antica Focacceria San Francesco serves a good range of Sicilian food and lies in the vicinity of this Palermo hotel.