Located about 25 minutes' walk from the 16th - century Messina Fountain of Neptune, the recently renovated B&B Regina 381 Messina includes a sun terrace and a picnic area.

The centre of Messina can be reached in 30 minutes' walk of this 4-star bed & breakfast, and such cultural venues as the Fountain of Orion are 2.9 km away. Church of the Annunciation of the Catalans in Messina is around 10 minutes' drive from the hotel. The Regina Messina is situated in proximity to the Passeggiata a Mare, while Capolinea Annunziata bus station lies a mere 600 metres away. Catania-Fontanarossa airport is located 115 km from the property.

This Messina hotel offers rooms with a dining area and a kitchen featuring an iron and ironing board, and an air conditioner, along with a flat-screen TV with satellite channels. They are appointed with a writing desk, and also feature coffee and tea making equipment. Guests will make use of dressing gowns and shower caps in bathrooms equipped with a bidet, a separate toilet, and a shower.

B&B Regina 381 serves an Italian breakfast in the morning. Take Away Messina features Italian dishes and is situated approximately a 5-minute walk away.