B & B B San Domenico Palermo includes 6 rooms and is 17 minutes' walk from the grand 9th century Norman Palace.

Regional Archeological Museum Antonio Salinas is around 400 metres away, while Palermo Central train station is in the vicinity of this bed & breakfast. The 14th-century Oratory of the Rosary of St. Cita Church is within 5 minutes' walk of the hotel, which is also located 6 minutes on foot from the Baroque Quattro Canti Square. The B & B B San Domenico is 2.1 km from Cuba Palace. Piazza Don Sturzo bus station is within a few blocks of this property.

The hotel offers rooms with a balcony and a dining area featuring air conditioning, along with a flat-screen TV with satellite channels. Guestrooms also include a fridge and kitchenware. Bathrooms inlude a bidet, a separate toilet, and a shower, and such fine comforts as a hair dryer and bath sheets.

The restaurant Antica Focacceria San Francesco lies within a 500-metre distance of B & B B San Domenico.