The 3-star Palazzo Sant'Isidoro By Domusicily Aparthotel Palermo includes air-conditioned rooms about 25 minutes on foot from the Foro Italico. This Palermo aparthotel lies in the Monte di Pieta district, in proximity to such cultural sights as Fontana Pretoria Fountain.

The hotel is only 0.9 km from Martorana co-Cathedral and just 450 metres from the 14th-century Oratory of the Rosary of St. Cita Church. Standing merely 9 minutes on foot from the 17th-century Church of the Gesu, the Palazzo Sant'Isidoro By Domusicily Aparthotel Palermo is approximately 30 minutes on foot from Giardino Inglese Garden. Located within a few blocks of the accommodation, the Church of Saint Catherine of Alexandria is open for visiting by worshippers and tourists. This hotel is 750 m from Roma - Poste bus stop and only 1.2 km from Palermo Central train station in Palermo.

The rooms at the Palazzo Sant'Isidoro By Domusicily Aparthotel are air-conditioned and fitted with wireless internet and a flat-screen TV with satellite channels as well as coffee and tea making equipment. The bedrooms come with sofa beds. Along with a bidet, a separate toilet, and a shower, the separate bathrooms also include a hair dryer and bath sheets.

Pizzeria Frida offers Sicilian meals and lies in close proximity to the property.