Offering a storage room, the comfortable Mariano Apartment Palermo hotel lies in Borgo Vecchio, which is one of the most folkloristic areas of Palermo, known for its street art works, 19 minutes' walk from the medieval Church of San Giovanni degli Eremiti and a mere 1.6 km from such cultural places of interest as the Gemmellaro Geological Museum. The 3-star guest house provides guests with Wi-Fi in public areas.

The hotel boasts a central location around 15 minutes on foot from Palermo Central train station, just near Teatro Massimo. The Mariano Apartment Palermo is also located 400 m from Chiesa di San Domenico Baroque Church and 600 m from the 17th-century Chiesa di San Giuseppe dei Teatini. There is the art museum "Palazzo Abatellis" just 1.3 km away, while Piazza Don Sturzo bus station is right around the corner from the property.

The rooms comprise a balcony and a sitting area complete with air conditioning, as well as complimentary wireless internet and a flat-screen TV with satellite channels. Other comforts include a refrigerator and kitchenware for self-catering. Bathrooms with a bidet, a separate toilet, and a shower, also offer a hair dryer and bath sheets.

The seafood restaurant Hawaii 13 is within easy reach of Mariano Apartment Palermo hotel.