Located 4.6 km from such natural attractions as the Giardino della Jardin de la Kolymbethra, the comfortable B&B Villa Luisa Apartment San Leone includes luggage storage. Guests can take advantage of private parking at additional charge on site.

The Greek Temple of Hera Lacinia lies around 10 minutes' drive away, while the ancient Temple of Concordia is around 15 minutes' drive from this 3-star bed & breakfast. You can find the crumbled Temple of Olympian Zeus Ruin, which is a great place to explore the area, 4.4 km from the Villa Luisa San Leone. There is the wheelchair-accessible Agrigento Regional Archaeological Museum approximately 20 minutes by car from the hotel.

The rooms comprise a patio and a dressing room complete with air conditioning, as well as a multi-channel TV. Other comforts include a fridge, an oven, and kitchenware for self-catering. Offering a bidet, a separate toilet, and a shower, the bathrooms are also fitted with a hair dryer and bath sheets. B&B Villa Luisa Apartment offers rooms with views of the garden.

The property serves Italian breakfast in the morning. The seafood restaurant Mi Sushi is located merely 1.9 km from this San Leone hotel.